Wise, the former NCAA champion from OR, shot 32 on the back nine with three birdies over the last five holes.
Day was at 10-under 203.
The Australian enjoyed a bogey-free back nine with birdies on 10, 12, 14 and 15 before closing out with pars to keep two shots ahead of Nick Watney and Aaron Wise.
The Rory McIlroy Majors remarks irked many as he casually added: 'I don't care about the US Open or the Open Championship.
McIlroy, a victor at Quail Hollow in 2010 and 2015, carded five birdies and two bogeys, to remain three shots behind leader American John Peterson, who posted a six-under 65. After a flat 2017 that was dulled by worries over his mother's health and a mild case of burnout after grinding to the top of the world, Day has returned with a renewed desire and focus this year.
That was nine shots off the pace set by American Peter Malnati, who fired a 68, including two birdies in his final three holes, to go with his opening 67.
The job Peterson has lined up is in real estate with a couple of his friends in Fort Worth so, after leading through 18 holes, would be annoyed now if he did make the criteria to keep his PGA Tour card? He won this tournament in 2007, but missed the cut the last two times he played in 2010 and 2012. Woods shot a 3-under 68 on Saturday to get under par for the tournament, but he's still struggling with his putter (95 putts over the first three days).
Uihlein, who is seeking his first PGA Tour win, didn't have much time to celebrate before being taken to be randomly drug tested.
There's a small, handwritten note in the Quail Hollow clubhouse that points out the course record and the direction of the first tee. Then, he was nine shots back after 36 holes but won by four after shooting 66-62 on the weekend.
When he sputtered at the start, there was no reason to panic that he wasn't taking advantage of a great day for scoring.
"I'm just not that comfortable with anything right now", McIlroy told Golf Channel.
At the conclusion of his round, Woods was six shots behind co-leaders Peter Malnati and Peter Uihlein. Fowler is 6 shots off the lead and McIlroy is 7 shots off the lead, but both are capable of going low and winning this tournament. "If I don't make it, I'm not playing golf anymore".
Masters champion Patrick Reed was among the later starters along with Tiger Woods and U.S. open champion Brooks Koepka. Now you're just getting greedy. "I know that there's a bunch of players in front of me that are trying to do the exact same thing and the guys behind me are trying to do the same thing".