Iranian President Hassan Rouhani said Tehran would remain in the global accord, but said that in "exiting the deal, America has officially undermined its commitment to an worldwide treaty".
And while the United States itself is not a major customer, foreign companies and other countries that continue to deal with Iran after the wind-down periods will face United States sanctions if they fail to reduce or end their trade. "As of today, the IAEA can confirm that the nuclear-related commitments are being implemented by Iran", he said.
Macron and other European leaders tried to convince Trump to remain in the deal, saying it would be better to be in the deal than out of it.
Trump said he definitive proof that Iran has violated the 2015 agreement aimed at freezing the country's nuclear ambitions.
In a statement, the Egyptian Foreign Ministry said it has followed the United States decision closely, and that it sees a need to preserve the "security and stability of the region".
Trump's decision to withdraw from the accord and reimpose sanctions on the Islamic republic overturns years of diplomacy, could worsen instability in the Middle East and threatens business in Iran worth billions of dollars.
Many Iranians are anxious about what Trump's decision could mean for their country.
He said it was up to the U.S. to spell out the way forward and he urged the administration not to take any action which would hinder the efforts of the other parties to make it work.
Guidance from the Treasury Department also suggested that flag administrations and maritime insurers would once more find themselves barred from doing business with Iranian entities, as could the long list of forwarders that recommenced commercial relationships with the country since the JCPOA was signed. So naturally, let's chuck the deal so they are free to build nukes, um, right now.
"I am particularly anxious by the announcement tonight of new sanctions", she said, referencing to Trump's plan reimpose economic sanctions on Ira.
Stated Boyle in part: "In 2015, I was one of 25 House Democrats to vote against the Iran nuclear deal (the JCPOA) because I believe it left too many important matters on the table".
French President Emmanuel Macron was due to speak later in the day to his Iranian counterpart Hassan Rouhani, Le Drian said.
We will stay in the agreement.
Meanwhile, for nations contemplating striking their own sensitive deals with Trump, such as North Korea, the withdrawal will increase suspicions that they can not expect lasting USA fidelity to worldwide agreements it signs.
But top USA officials were already working to stymie efforts by European powers to go ahead with business deals they undertook when sanctions on Iran were lifted in 2016.
Mr Johnson's comments came amid fears that the reimposition of USA sanctions could hit European firms - which have led the way investing in Iran under the JCPOA - particularly hard.