Israel said its Thursday strikes were in response to a barrage of Iranian rockets on its positions in the occupied Golan Heights, the most serious military confrontation between the two bitter enemies to date.
Iran has been active in Syria since the start of the uprising in 2011, which led to the horrific civil war that continues to play out today. The rockets that did not fall short on their own were destroyed by Israel's formidable missile defense system - Iron Dome - before they could cause any damage.
The Russian Ministry of Defense said 28 Israeli F-15 and F-16 warplanes took part in the raids, firing a total of about 70 missiles.
The reports were confirmed by a Syrian military commander speaking to Reuters, who said that the strikes hit a Syrian military base.
Israel views Iran as its archenemy, citing Iran's calls for Israel's destruction, support for militant groups across the region and growing military activity in neighboring Syria.
In a rare expression of support, Bahraini Foreign Minister Sheikh Khalid bin Ahmed al-Khalifa twitted on Thursday that Tel Aviv had a right to "defend itself" after Israel said it carried out some 50 raids inside Syria. An Israeli army spokesman, Avichay Adraee, said on Twitter that Israel was "acting against Iranian targets inside Syria", a rare admission by an Israeli official.
Tensions have escalated at a frightening pace between Iran and Israel in the three days since President Donald Trump said he was pulling the United States out of the Iran nuclear deal.
"Israel has responded forcefully to violations of its red lines".
Rouhani did not mention Israel's strikes in Syria early on Thursday, or those against the Israeli-occupied Golan Heights, also on Thursday.
Imagine if Iran regularly fired at Israeli military posts, the world would lose its mind. Within Iran, it could empower hardliners while weakening the moderate camp that has sought better relations with the West.
But he insisted Israel had "no interest in escalation" of the situation, adding: "I hope that we have finished this chapter and that everyone got the message".
Iran's Foreign Ministry strongly condemned Israel's attacks and called it a blatant violation of Syria's sovereignty. But the White House has repeatedly claimed the strikes targeted "Israeli citizens".
It is one of the biggest attacks against Israel from Syria in decades. He said it will not allow Iran to turn Syria into a forward military base against the Jewish state.
In the nuclear field, Russian Federation has already built one reactor at Iran s Bushehr plant, the country s only nuclear power plant, and has started work on two new ones. For Israel, though, she said it's "really hard to pick a dog in this fight".
Israel's military spokesperson Lieutenant Colonel Jonathan Conricus said earlier that Israel had retaliated for an attack on its outposts in the strategic Golan Heights plateau.