Not surprisingly, Israeli Prime Minister Benjamin Netanyahu hailed Trump's decision and said that leaving the deal unchanged would be "a recipe for disaster, a disaster for our region, a disaster for the peace of the world".
North Korea can and likely will use the White House's decision to rip-up the Iran nuclear deal as a reason to stand firm on certain aspects of a proposed denuclearization agreement during negotiations.
For now, this splits the US and its major European allies and exacerbates tensions with China and Russian Federation, who also joined the 2015 Iran deal.
Pointing also to the USA withdrawal from the Paris accord on climate change, Merkel added: "If we always say that, if we don't like things and we can't achieve a new worldwide order, everyone will do what they feel like, that's bad news for the world".
The Iranians began protesting shortly after the Friday prayers as they carried banners, reading: "Down with the US" and pictures of Trump with a caption: "Go to hell". Now it's up to the Iranians and other countries involved in the deal to help the world stave off that unnerving possibility.
The White House is demanding the existing inspection regime, however imperfect, continue under the aegis of the International Atomic Energy Agency, the United Nations nuclear watchdog.
Iran has always denied seeking a nuclear weapon, insisting its atomic program was for civilian purposes. In April, CEO Dennis Muilenburg told investors that the company had pushed back delivery plans for the first Boeing 777 jets it was scheduled to deliver to Iran this year.
Under the deal reached in 2015 between Iran and six major powers, Tehran agreed to curb its nuclear programme in return for lifting most worldwide sanctions that crippled the country's economy.
Ayatollah Ali Khamenei's comments came Wednesday as he met with a group of school teachers in Tehran, a day after Trump announced he was renewing sanctions on Iran. They hobbled Iran's economy, for instance, and it has not recovered, despite the regime receiving much of the deal's financial benefit upfront. Most of all, I am alarmed that Mr. Trump's decisions may well set the United States on the path to an unnecessary, devastating war with Iran. She added this is time for Europe to take its destiny into its own hands.
The IAEA has so far confirmed that Iran is adhering to its "nuclear-related commitments", although the United States administration questions that conclusion.
It's not yet clear how Iran will respond, though Iranian President Hassan Rouhani responded to Trump's decision with a warning his country could resume enriching uranium within weeks. It also held out hope for resolving other contentious issues with Iran, such as ballistic missile development and its involvement in the Syrian and Yemeni conflicts, by diplomacy.
Trump announced Wednesday that the USA would no longer be part of that deal.
The Kremlin said Russian President Vladimir Putin is "deeply concerned" by the withdrawal, the RIA news agency said.
"If we achieve the deal's goals in cooperation with other members of the deal, it will remain in place", he said.
That means the U.S. can effectively decide whether companies of other countries trade with Iran or not.