She said Ryan has given "his all" to a job that's more a lifestyle than a job. "It's a big job with a lot riding on you, and you feel it".
Hoping to push forward on conservative legislation, Ryan worked with the president more than against, but he was still - on a near-daily basis - quizzed by reporters on the latest Trump tweet or sound-off.
Walking down the memory lane, Ryan noted that he took the job "reluctantly" in 2015, adding that he had no "regrets". "So I will be setting new priorities in my life, but Ill also be leaving incredibly proud of what we have accomplished", Ryan said.
Mr Ryan, who portrayed his decision as one driven by wanting to spend more time with his family, has had a rocky relationship with Republican President Donald Trump. The speaker will still want to help with the recruitment of new members, with fundraising and the ground game for the GOP. For months the speaker has battled rumors about his retirement.
Looming in the aftermath of Ryan's announcement is the reality of an impending leadership race that will now stretch for months ahead of a contentious midterm election. "Paul has challenged us all to raise our gaze, and he is deeply respected on both sides of the aisle because of his principles and commitment to the American idea".
Speaking in Washington on Wednesday, Ryan said his decision to retire was not based on a fear of losing his party's majority in the House. And now Ryan is on his way out, meaning that, within a decade, two of the three Young Guns authors will have left politics. "There's two people I think Putin pays: Rohrabacher and Trump", said Kevin McCarthy (R-Calif.), in an exchange recorded and later reported by The Washington Post. Ryan spoke of his successful efforts to increase defense spending in the $1.3 trillion appropriations bill passed in March and to pass tax reform in December of previous year. Typically, in recent years, speaks tend to hand over the gavel either when their party loses the majority, or when their own caucus decides it's time to go.
Ryan, 48, announced his plans at a closed-door meeting of House Republicans early this morning, according to those present. Ryan doesn't seem like a fan of his, either, and he could be making a calculated decision to sacrifice his power for the greater good.
Scalise demurred when asked if he would run for the speakership.
Sometimes we forget - congressional leaders have districts and constituents to think about, too. That is what I'm told is the politically shrewd thing to do.
More than three dozen House Republicans have said they are retiring, or running for another office, or resigning.
Ryan's independent campaign committee, Paul Ryan for Congress, is also a source of major campaign reserves for anyone running for public office. They often become lightning rods for political partisanship.
House Speaker Paul Ryan's leadership lieutenants say it's not yet time to jockey to succeed him. "But that effort was derailed by a handful of myopic Republican senators. We should all be grateful for his sacrifice and understand his desire to be a full time Dad". Several GOP members have either retired or are facing tough re-election campaigns.
In 2011, he gave the Republican response to then-President Barack Obama's State of the Union deal with. There has been speculation that Ryan could have his eye on a run for the White House in 2020 or beyond. "He will be successful in any future endeavor and I wish him all the best".
Former Democratic Speaker Nancy Pelosi tempered her praise for Ryan.