Liverpool continued to dictate possession and knew that a second goal could well kill the game off, and it came through a marvelous series of passes through the middle of the pitch, allowing Mane to finish expertly in front of the Kop. It was a save that kept Liverpool in control going into the second half and topped off recent impressive saves he has been called upon to make.
They frustrated Liverpool's determination to move the ball forward.
The 25-year-old has made a brilliant start to life at Anfield since his move from AS Roma in the summer transfer window.
It was the first time that Liverpool have beaten a Rafa Benitez side as Jurgen Klopp kept his promise of giving the former manager no favors.
"I think it's hard for the Premier League to find solutions", said Benitez.
The result leaves Liverpool second in the table until at least Monday night when Manchester United take on Crystal Palace, whereas Newcastle remain just two points clear of the relegation zone despite falling to only their second defeat in their last nine league outings.
Newcastle manager Rafael Benitez thanked the Liverpool fans for his warm reception on his returned to Anfield, as he admitted his team had been outclassed.
Since he joined the club at the end of December with Swansea bottom, the team has won five league games and lost only two.
The second half started just the way it ended for Klopp's men. It was also Mohamed Salah's 24th league goal in the current campaign and the Egyptian now sits at the top of the 2017-18 Premier League goalscorers list.
"It is about end product, scoring goals, setting up goals as an attacking player and that is what I have to keep doing", he said.
"There are a lot of football clubs around and if they pay then it's normal that a player thinks about it". Since he was appointed, only Man City (214) have scored more often in the competition.
The same is not true of Liverpool, whose 65 league goals is 12 more than any team but City have managed this season. Sadio Mane struck the other goal for the Reds.