The UN's International Commission of Inquiry on Syria said it was "extremely" troubled by the recent uptick in violence in Idlib province and rebel-held areas in the Eastern Ghouta suburbs of Damascus, where hundreds have been killed in raids since the beginning of the year.
Since then, activists say Russian and Syrian government forces have stepped up their attacks.
The Syrian Observatory for Human Rights, a Britain-based war monitor, said the missiles targeted "positions of the Syrian army and its allies" in the region of Jamraya, west of Damascus, which was also hit in December.
The bloodshed comes a day after another 31 civilians were killed in Eastern Ghouta and as the.
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The YPG were largely responsible for the eradication of the Islamic State (ISIS) from much of Syria, including the former ISIS "capital" Raqqa, and work with the United States, Russia, and nearly any anti-jihadi forces on the group.
A separate crisis is developing east of Damascus, in the rebel-held enclave of Ghouta, where over 400,000 people surrounded by government forces have been reliant on United Nations aid for the past four years. He labelled the government siege and indiscriminate shelling of eastern Ghouta "international crimes". It said it ongoing fighting and the deliberate obstructions by forces at the front lines were blocking aid organizations from reaching civilians in need.
"If access was granted, three convoys could be dispatched each week, reaching over 700,000 people in these areas in two months", the United Nations said.
The White Helmets said three of its rescuers and six other people suffered breathing problems.
Another nine civilians, two of them children and one a local rescue worker, were killed in Arbin. "Some 135,000 refugee brothers and sisters in Turkey who have come from Syria have returned to their homes", Erdoğan said.
Several children were among Monday's dead. "I think that has earned them a seat at the table", he said. After a shootout with the attackers on the ground, Filipov blew up himself with a hand grenade.
This is the first time a Russian fighter jet was shot down since Russia began its aerial military campaign in support of Syrian government in 2015, according to the BBC.
President Recep Tayyip Erdogan and Russian counterpart Vladimir Putin agreed to hold the summit in Istanbul alongside Iranian President Hassan Rouhani in telephone talks on Thursday, a Turkish presidential source said.