Pogba has started from the substitutes' bench twice in United's past four matches, as his relationship with Mourinho becomes increasingly strained.
United were criticised after Wednesday's goalless draw at Sevilla as the Spanish outfit were unfortunate not to secure a surprise victory.
The Italian will have a hard decision to make regarding his forwards, after he elected to choose Willian, Pedro and Eden Hazard to lead the line against Barcelona, with Alvaro Morata and Olivier Giroud sitting on the bench.
However, United cannot afford to lose on Sunday as a defeat could most definitively drag them down to a scrap for fourth.
If the Ivorian is fit and available, Mourinho is likely to deploy a three-man back-line as has often been the case against sides with similar systems during his reign as the Manchester United manager.
"My expectation is to see him on the pitch". Same result but completely different performance.
Sevilla would take at least a 2-0 lead into the second leg of their Champions League tie with Manchester United if not for David de Gea.
Marcos Rojo and Phil Jones are still out, which means Chris Smalling and Eric Bailly, for the first time since a year ago, could start together.
The man bought in as Matic's replacement, Tiemoue Bakayoko has been slow to adjust to life in the Premier League. "If we play the semi-final of the FA Cup, I don't know when that will be so it can be really busy and complicated".
History shows the Reds are leading the head-to-head record comfortably, with 73 wins to Chelsea's 52 from 178 meetings.
What time is the kickoff between Manchester United vs Chelsea in the English Premier League? "But our situation doesn't change; we have to prepare for the game". On Sunday's crunch fixture, the Manchester United boss could be without as many as six first-team players due to various fitness problems.
It could not have gone any worse for the Portuguese as his side were hammered 4-0, through goals from Pedro, Gary Cahill, man of the match Eden Hazard and N'Golo Kante, with Antonio Conte giving him a tactical masterclass.