This was Williams' first match since police in Florida rescinded their original conclusion that she was at fault in a two-car crash last month.
If that wasn't enough, here's some added spice: it will also be the first time the pair have met in a competitive environment since an ill-tempered Fed Cup clash between Romania and Great Britain in April.
"Even sometimes on the WTA Tour when there is (legal) coaching and they can come on court, it's not making any difference, either, because maybe you have one minute to talk and it's not making any difference. I think it's very hard for them to understand my position", she said.
Not for 44 years have a British man and woman made the singles quarter-finals in the same year, and hopes are high that this may not be the end of the story.
In July a year ago, she claimed her first WTA Tour title at the Bank of the West Classic in Stanford with a 7-5 5-7 6-2 win over Venus Williams.
"You will have to ask me what it feels like when I'm retired", Williams said.
Konta was born to Hungarian migrant parents in Sydney, Australia. Her dad is a hotelier and her mum a dentist. She can also speak the language.
Garcia was once tipped as a future world number one by Andy Murray but her career has so far failed to ignite.
Johanna Konta has reiterated that she relishes being involved in tough contests on the biggest stages. Muguruza hasn't won a title in 2017, but she reached the round of 16 at the French Open and the quarterfinals at the Australian Open. The game is scheduled to start no sooner than 15:00. In 2014, she switched her training base to Gijon in Spain working with her Spanish coaches Esteban Carril and Jose-Manuel Garcia.
The interview, which made the quote of the day slot on the highlights show, saw Konta reveal how she'd given her team "white chocolate and raspberry muffins" yesterday and that she was buoyed by the "positive feedback".
Sixth seed Konta is through to the quarter-finals at the All England Club and will take on French Open runner-up Simona Halep - the only remaining player above her in the rankings - on Tuesday.
However, as she has said before, it does not take much for the momentum to shift, as Garcia struck twice in a row to build up a 5-1 lead.
If Halep loses before the last four, then Czech world number three Pliskova will be the new number one despite losing in the second round. The Konta match was at it's most exciting and suddenly it switches to Murray. She has everything-except the one thing everyone has expected from her for years: a Grand Slam title.
Konta has mostly breezed other than the aforementioned match with Vekic.
"But it's not easy to do it over a 12-month period".
Williams' quarter-final opponent, Latvia's Jelena Ostapenko, was just 11 when Venus won the last of her five Wimbledon titles in 2008.