But the barrel-chested "Stanimal" was powerless as Nadal turned the final into an exhibition of his clayclourt supremacy - taking his French Open record to an eye-watering 79-2.
"It's true that 10 is a attractive number, but actually my favourite is nine", said Nadal, the nine-time champion at Roland Garros.
The Spaniard became the first player to win 10 titles in any Grand Slam tournament in the Open Era.
Nadal owns 53 clay trophies after adding his tenth at Roland Garros to the 10 he won at both Monte Carlo and Barcelona over the last three months.
Nadal is 9-0 in French Open finals.
Nadal extended his match wins tally to a 43-6 record, including a 24-1 stretch on clay.
Nadal acknowledged afterward that he dealt with a real case of jitters while he waited for the final to resume Monday after it was suspended in the fourth set because of rain Sunday night.
"For sure he's playing the best he's ever played, not only here", Wawrinka said.
The third-seeded Wawrinka of Switzerland was vying for his second Roland Garros title, winning in 2015 for one of his three major championships. "To win a 10th time here is very special for me".
While Nadal lifted the Coupe des Mousquetaires, a huge banner was unveiled in the stands saying, "Bravo Rafa".
"For me this event is the most important one of the year and I have more pressure on me, but it is not just about the four grand slams", he said.
"I didn't play my best tennis", said Wawrinka at the conference. Nadal also paid an emotional tribute to his uncle and lifelong coach Toni Nadal, who will step aside from his role at the end of the season. And I finished the year being World No. 1, winning here (in Paris), winning the US Open. It is hard to compare this tournament to any other one. It always looked like it was going to be a Nadal match. "It's aways a honour to play against you", said Wawrinka. "Congratulations on your career, to you and to all your team".
With Federer, 35, having won this year's Australian Open, this is the first time since 1972 that a man 30 years of age or older has won the first two Slams of a calendar year.
"The King of Clay" won French Open number nine and record fifth successive time in defeating rival Djokovic in four sets. But the 2015 champion could not convert it and it proved to be the only break point he earned all afternoon.
From there, it was all downhill.
Wawrinka, who spent almost five hours more on court than Nadal to reach the final, looked tentative and heavy-legged although he did have a glimmer in the third game when Nadal was forced to save a break point. She then had three break points to move to 4-0.
He lost the next two points as well to give Nadal another break and the Spaniard raced across the finish line. The third-ranked Swiss was coming off a title in Geneva, won his first five rounds at Roland Garros all in straight sets, and beat world No. 1 Andy Murray in a five-set semifinal.